We employ automation, artificial intelligence, and quantitative strategies to produce retinal and other organoids from human, tree shrew, and mouse stem cells. We are particularly interested in using this fascinating model to test therapies, study cell-cell interaction, model diseases and produce retinal ganglion cells for transplantation.
We perform deep advanced analysis of single-cell RNA-, ATAC-, ChIP-, VDJ-, and spatial-seq data, focusing on cell specification, maturation, and cell-to-cell communication in disease and regeneration. Species include humans, dogs, mice, and axolotl.
Organoids: retina and beyond
Integrated multi-omics analysis
Transplantation and cell therapy development
The retina of the eye provides a unique setting to study and control donor cell fate on a single level. The lab focuses on cell transplantation, emphasizing the microenvironment and its role in donor cell maturation and integration.